Technological features of multi-layer tubular hydrogel products manufacturing
Students Name: Berezhnyy Bohdan-Volodymyr Vadymovych
Qualification Level: master (ESP)
Speciality: Chemical Technology and Engineering
Institute: Institute of Chemistry and Chemical Technologies
Mode of Study: full
Academic Year: 2022-2023 н.р.
Language of Defence: англійська
Abstract: Relevance of the work. The creation of synthetic materials for the manufacture of vascular prostheses and implants with improved properties is an urgent task due to the deficit of healthy blood vessels to replace damaged areas of arteries and veins. Unlike most synthetic products used in medicine, blood vessel prostheses are developed in such way that their characteristics would be as close as possible to natural vessels. Currently, none of the synthetic prostheses is perfect and has a number of certain disadvantages: they lead to various complications related to structural defects, lack of compliance, dilatation, high blood resistance and obstruction, in many cases during operation they are short-lived due to thrombosis and insufficient healing process. Owing to their unique properties –elasticity, resilience, sufficient porosity, high chemical and biological inertness, antithrombogenicity, sorption capacity for low molecular weight substances, permeability to liquids and gases –polymer hydrogels are considered promising materials for the manufacture of vascular prostheses. However, the disadvantage that limits the use of hydrogels for vascular 8 prostheses is their insufficient strength characteristics, as well as absence of technology for the production of tubular products. Therefore, the issue of developing new hydrogel materials with increased strength, suitable for the manufacture of vascular prostheses and simple technologies for their production, remains open, and research related to its solution has to be continued.