Synthesis of magnetic nanoparticles for biomedical application
Students Name: Vasylyshyn Taras Mykhailovych
Qualification Level: master (ESP)
Speciality: Chemical Technology and Engineering
Institute: Institute of Chemistry and Chemical Technologies
Mode of Study: full
Academic Year: 2019-2020 н.р.
Language of Defence: ukrainian
Abstract: This paper describes research on the synthesis of magnetic nanoparticles with a high degree of monodispersity, as well as magnetically filled polymer composites based on polyacrylamide and polysaccharide hydrogels. A thorough analysis of the literature has confirmed the relevance of the use of chemical synthesis methods to obtain magnetic nanoparticles (MNP). Magnetic magnetite nanoparticles were synthesized by liquid-phase chemical condensation (Elmore) and thermal dissociation of organic iron salts, a comparison of these methods was performed, the main properties of the obtained particles were characterized, and the dependence of their properties on synthesis parameters was described. In the paper method of obtaining highly monodisperse nanoparticles of magnetite was developed, as well as the introduction of the obtained particles into the matrix structure of hydrogels based on polyacrylamide and polysaccharides, the results of research of physical and mechanical properties of the synthesized MNP and hydrogels on their basis are presented. The developed composite systems can be used to create systems for targeted delivery of drugs, biologically active substances, enzymes in medicine, cosmetology and biotechnology, as well as sensors and contrast agents in diagnostics. The cost of the investigation was also calculated. Keywords: magnetic nanoparticles, magnetite, magnetically sensitive polymer composites, functionalized hydrogels.