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Pharmaceutical and Medical Biochemistry
Major: Chemistry
Code of subject: 8.102.00.M.031
Credits: 3.00
Department: Technology of Biologically Active Substances, Pharmacy and Biotechnology
Lecturer: ass. professor Marintsova Nataliya Henadiivna
Semester: 4 семестр
Mode of study: денна
Завдання: Knowledge of theoretical foundations and applied principles of chemistry, understanding of modern trends in the development of chemical science. In-depth understanding of processes of organic synthesis, mechanisms of chemical reactions, prediction of properties of new promising products of organic synthesis; Understanding of modern scientific theories and methods of synthesis of biologically active compounds and medicinal products, their identification , quality and purity control.
Learning outcomes: The ability to identify the correspondence between the structure of a substance, its physical and chemical properties, reactivity and methods of its synthesis. The ability to carry out qualitative and quantitative analysis of raw materials, semi-products and finished products of chemical and pharmaceutical industries according to the given methodology. Demonstrate in-depth knowledge of the process of creating drugs, starting from the moment of the idea of ??synthesizing a substance of a certain structure, conducting screening and improving the structure, close to the stage of clinical trials and the organization of production; demonstrate in-depth knowledge of targets, pharmacokinetics and metabolism of medicinal substances in the body, as well as methods of quantitative assessment of the "structure-activity" relationship; demonstrate in-depth knowledge of experimental methods necessary for understanding biochemical processes.
Required prior and related subjects: • Methods of fine organic synthesis
Co-requisites:
• Quality assessment of medical and pharmaceutical technologies (quality of drugs, quality of treatment)
• Application of medicines in clinical practice (advanced pharmacotherapy study)
Summary of the subject: The purpose of this discipline is to form a holistic view of the process of drug creation in students, starting from the moment of the idea of synthesizing a substance of a certain structure, carrying out screening and improving the structure, to the stage of clinical trials and organization of production. In this discipline, topics that allow obtaining information about targets, pharmacokinetics and metabolism of medicinal substances in the body, about modern approaches in the design of drugs and types of pharmacological research of new chemical compounds, as well as about methods of quantitative assessment of the relationship "Structure - activity" are considered.
Опис: Relation of physicochemical properties of biologically active compounds with their pharmacological activity. Drug-receptor interaction. Metabolism of biologically active substances. Metabolic pathways and sites of xenobiotic metabolic changes. Transport of drugs through membranes. Relationship of structure and metabolism degree of medicinal substances. Biochemical transformation of medicinal substances in the body. Factors that affect drug metabolism. Biological studies of new compounds. Stages of development drug compounds. Quantitative ratio structure-activity. Regression models of biological activity of organic molecules. Statistical methods of molecules classification by their biological activity.
Assessment methods and criteria: The main methods of knowledge diagnosis are: current (PC) and semester control (SC), which is carried out from educational material, the scope of which is determined by the work program of the discipline for the semester. Current control is carried out during lectures and laboratory classes in order to check the level of assimilation of theoretical and practical knowledge and skills of the student. PC is conducted in the form of: written express control (individual tasks) and defense of laboratory work. Semester control is conducted in the form of an exam (EC). The exam is a form of SC of the results of the student's studies in the academic discipline for the semester.
Критерії оцінювання результатів навчання: • Summary control - 100 points ( control, exam): written-oral form.
Порядок та критерії виставляння балів та оцінок: 100–88 points – (“excellent”) is awarded for a high level of knowledge (some inaccuracies are allowed) of the educational material of the component contained in the main and additional recommended literary sources, the ability to analyze the phenomena being studied in their interrelationship and development, clearly, succinctly, logically, consistently answer the questions, the ability to apply theoretical provisions when solving practical problems; 87–71 points – (“good”) is awarded for a generally correct understanding of the educational material of the component, including calculations, reasoned answers to the questions posed, which, however, contain certain (insignificant) shortcomings, for the ability to apply theoretical provisions when solving practical tasks; 70 – 50 points – (“satisfactory”) awarded for weak knowledge of the component’s educational material, inaccurate or poorly reasoned answers, with a violation of the sequence of presentation, for weak application of theoretical provisions when solving practical problems; 49-26 points - ("not certified" with the possibility of retaking the semester control) is awarded for ignorance of a significant part of the educational material of the component, significant errors in answering questions, inability to apply theoretical provisions when solving practical problems; 25-00 points - ("unsatisfactory" with mandatory re-study) is awarded for ignorance of a significant part of the educational material of the component, significant errors in answering questions, inability to navigate when solving practical problems, ignorance of the main fundamental provisions.
Recommended books: 1.N.H.Marintsova N.H., S.V. Polovkovych, V.P.Novikov. Biolohichna khimiya. –L.:NU»L?vivs?ka politekhnika», 2013. -336 s. 2.V.P. Muzychenko, D.D.Lutsevych, L.P.Yavors?ka. Medychna khimiya. Kyyiv, VSV «Medytsyna», 2018. – 496 s. 3.R. Marri, D. Hrenner, P. Meyes, V.Roduell. Biokhimiya lyudyny v 2-kh tomakh. – Moskva, «Myr» 4.S. Anhel?s?ki, M.H. Dominichak, Z. Yakubovski. Klinichna biokhimiya. – Sopot, «Persey», 2000. – 451 s.
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