Project of m-nitrobenzoic acid production technology
Students Name: Beniuk Sofiia Vasylivna
Qualification Level: magister
Speciality: Pharmaceuticals Technologies
Institute: Institute of Chemistry and Chemical Technologies
Mode of Study: full
Academic Year: 2020-2021 н.р.
Language of Defence: ukrainian
Abstract: Benyuk S.V.; Kurka M.S. (head). "Project of m-nitrobenzoic acid production technology". Master’s thesis. - – Lviv Polytechnic National University, Lviv, 2020 Extended abstract Study object - m-nitrobenzoic acid production technology. Scope of research - industrial synthesis of compounds for pharmaceutical industries. Purpose of research - development of a convenient and effective preparative method for the synthesis of m-nitrobenzoic acid and the way of introduction of the synthesized drug into production. Implementation of the necessary material and technological calculations, selection of equipment, development of technological scheme of production, implementation of economic calculations. The project of m-nitrobenzoic acid production technology has been developed which includes the organization of production, the characteristic of raw materials, basic technological scheme of production, target production. m-nitrobenzoic acid is used in practice as an antimicrobial agent in the microcrystalline identification of alkaloids, as well as in the deposition and separation of elements such as cesium, zirconium, mercury, hafnium. m-nitrobenzoic acid is a derivative of benzoic acid, which is used in medicine as a fungicide, in diseases and fungal skin lesions. In the presence of structure nitro groups of m-nitrobenzoic acid shows more pronounced antimicrobial activity than benzoic acid, but also higher toxicity. In addition, m-nitrobenzoic acid is a precursor of aminobenzoic acid, which is a component of folic acid and is involved in the synthesis of nucleic acids and other biologically active substances. The relevance of research in this area is expressed by the fact that the introduction of nitro groups into the molecule of benzoic acid allowed to combine the valuable properties of benzoic acid and nitro and amino derivatives. This makes it possible to expand the range of biologically active compounds of this series. A review of the literature on the general characteristics of m-nitrobenzoic acid is performed, the main methods of synthesis and reaction of chemical interaction are given. The material balance of all stages of m-nitrobenzoic acid production is made, technological and thermal calculations are executed. Based on them, technological equipment was selected, a basic technological scheme was developed and the building of the m-nitrobenzoic acid production plant was designed. The basic technological scheme of m-nitrobenzoic acid production technology is developed and designed. Sulfuric acid is charged into the reactor P-1, equipped with a jacket, anchor stirrer from the storage Cx-1 through the meter M-1. Heat it to a temperature of 85?C and load a mixture of benzoic acid and potassium nitrate. After cessation of the mixture, the reaction mass is heated to a temperature of 95?C and kept for 5 hours. The mixture is cooled and transferred to the K-1 crystallizer, where distilled water was previously loaded. The reaction mixture is kept under stirring for 6 hours and pressed on the DF-1 filter filter. The filtrate is collected in the collection Zb-1, and the precipitate is washed with distilled water directly on the filter partition. The water used to wash the precipitate is collected in the collection Zb-1. The washed precipitate from the filter partition is manually transferred to the reactor P-2, equipped with a jacket, anchor stirrer and direct refrigerator, where previously distilled water was loaded. The reaction mixture is heated to a temperature of 100?C. Connect the steam feeder and distill off the remnants of benzoic acid, which is collected in the collection Zb-2. The residue is washed with water and pressed on the DF-2 filter press. The filtrate is collected in the collection Zb-3, and the precipitate from the filter partition is manually transferred to the mold K-2, which is pre-loaded from storage Cx-2 through the meter M-2 ethanol for recrystallization of m-nitrobenzoic acid. The mixture is heated to 78?C, and then slowly cooled. The formed crystals of m-nitrobenzoic acid are pressed on the printing filter DF-3. The filtrate is collected in the collection Zb-4, the precipitate from the filter partition DF-3 is transferred for drying in the dryer Ssh-1. The dried m-nitrobenzoic acid is sent for packaging and labeling. The technical and economic indicators were calculated in the work and the economic expediency of this work was proved. Based on the work, conclusions were made about the relevance and feasibility of this project. Key words: m-nitrobenzoic acid, production technology, material balance, technological scheme, project calculation. 1. Stasevych M.V., Mylanych А.О., Strelnikov L.S., Krutsky T.V., Buchkevych I.R., Zaitsev O.I., Guzyova I.O., Sagittarius O.P., Gladukh E.V., Novikov V.P. (2018) Technological equipment of the pharmaceutical and biotechnological industry The textbook for university students III-IV levels of accreditation, Lviv