Development of an antidiabetic biologically active supplement based on inulin-containing chicory raw materials
Students Name: Hrabchak Volodymyr Volodymyrovych
Qualification Level: master (ESP)
Speciality: Biotechnology and bioengineering
Institute: Institute of Chemistry and Chemical Technologies
Mode of Study: full
Academic Year: 2022-2023 н.р.
Language of Defence: ukrainian
Abstract: Grabchak V.V.; Vasylyuk S.V. (supervisor). «Development of an antidiabetic biologically active supplement based on inulin-containing chicory raw materials». Master`s thesis. – Lviv Polytechnic National University, Lviv, 2023. Extended abstract Study object - medicinal plant material - chicory root Radix Cichorii intybi. Scope of research – antidiabetic biologically active supplements. Goal of research – search for the optimal technology for obtaining chicory root extract for the development of an antidiabetic biologically active supplement from inulin-containing chicory raw materials. According to the WHO, there are more than 420 million people with diabetes in the world, and its prevalence is steadily increasing. In terms of prevalence, diabetes ranks third after cardiovascular diseases and oncological diseases. Treatment of diabetic patients with synthetic drugs is often accompanied by undesirable side reactions, for example, frequent allergies, in the event of which it is necessary to replace the drug with a drug belonging to another group or an analogue of another manufacturer. The use of inulin-containing biologically active supplements based on natural raw materials is becoming more and more relevant for the treatment of type 2 diabetes. In particular, chicory raw materials attract a lot of attention. Since the natural extract of inulin-containing chicory raw materials does not cause adverse reactions and does not require further replacement. In diabetes, chicory root is used, which contains inulin in significant quantities (up to 75% in the dried root). In the human body, chicory is quite easily absorbed, contributing to the improvement of digestion, metabolism and reducing the level of sugar in the blood. In addition, the use of chicory helps to cleanse the body of heavy metals, radioactive substances, toxins and slags, which is an additional positive factor for improving the health of patients with diabetes. The master’s thesis is devoted to the search for the optimal technology for obtaining chicory root extract for the development of an antidiabetic inulin-containing biologically active supplement necessary for patients with diabetes, as well as people at risk of this disease. In the main part of the work, the justification of the current state of the problem of diabetes therapy was carried out, the assortment of biologically active supplements with chicory root extract on the pharmaceutical market of Ukraine was investigated, and the optimal technology of chicory root extraction was selected to obtain an antidiabetic biologically active supplement. In the economic part of the work, technical-economic indicators were calculated and the economic feasibility of this work was proved. The conclusions formulated in the paper are in accordance with the literature data and are based on experimental material using modern research methods Key words: diabetes, biologically active supplements, inulin-containing raw materials, chicory root Radix Cichorii intybi References: 1. Paglialunga, G.; Proietti, S.; Cardarelli, M.; Moscatello, S.; Colla, G.; Battistelli, A. Chicory Taproot Production: Effects of Biostimulants under Partial or Full Controlled Environmental Conditions. Agronomy 2022, 12, 2816. https:// doi.org/10.3390/agronomy12112816. 2. O. Yezerska, T. Kalynyuk, L. Vronska Quantitative determination of hydroxycinnamic acids in chicory root/ // Сhemistry and Chemical Technology. – 2013.– No 3. – P. 247-250. 3. Lee J, Noh S, Lim S, Kim B. Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery. Antioxidants (Basel). 2021 Jan 9;10(1):81. doi: 10.3390/antiox10010081. PMID: 33435282; PMCID: PMC7827314. 4. Stokle K, Kruse A (2019) Extraction of sugars from forced chicory roots. Biomass Conv Bioref 3:699–708. https://doi.org/10.1007/s13399-019-00374-9.