Chemistry of Carcinogens

Major: Biotechnology and Bioengineering
Code of subject: 6.162.01.E.052
Credits: 4.00
Department: Technology of Biologically Active Substances, Pharmacy and Biotechnology
Lecturer: Associate Professor, Ph.D. Olena Iaremkevych
Semester: 5 семестр
Mode of study: денна
Мета вивчення дисципліни: The discipline "Chemistry of carcinogens" is one of the main courses taught for students of specialty 162 "Biotechnology and bioengineering". The main goal of studying this discipline is to acquire and assimilate knowledge about carcinogenesis, the classification of pollutants and xenobiotics, the degree of their carcinogenicity, sources of pollution of the environment, food products, drinking water, possible chemical modifications of carcinogens when they penetrate bioproducts and negative effects on the human body.
Завдання: professional competences: FK01.11. The ability to use knowledge about the impact of harmful factors on the health of living organisms, the methodology for determining the toxicity of xenobiotics in the environment and the processes of provoking oncogenesis.
Learning outcomes: - Ability to use knowledge about the impact of harmful factors on the health of living organisms, the methodology for determining the toxicity of xenobiotics in the environment and the processes of provoking oncogenesis; - Ability to apply basic knowledge about the sources and types of carcinogens to prevent their harmful effects on the human body through the consumption of water, food and human exposure to environmentally hazardous environments; - Ability to organize work in accordance with the requirements of life safety and labor protection; - Ability to use knowledge and practical skills to choose quality food products (raw materials) to ensure their own and socially harmonious development and health; - Ability to use knowledge of modern methods of prevention, diagnosis and treatment of cancer. - Ability to demonstrate an understanding of the basics of environmental protection and life safety; - Ability to apply modern experimental methods to assess water and soil quality in the laboratory and in production conditions.
Required prior and related subjects: Prerequisites: General and organic chemistry; Hygiene and asepsis and ecomonitoring; Fundamentals of labor protection and life safety; Hygienic basics of food safety. Co-requisites: Technological practice; Bioengineering (cellular and genetic); Biodamage and biotransformation organic compounds.
Summary of the subject: General principles of carcinogenic hazard. Sources of pollution of the biosphere by organic and inorganic carcinogens (nature disasters, man-made disasters, metabolic transformation, anthropogenic emissions). Pollution of food by heavy metals, radionuclides, nitrates and nitrites, microbial metabolites. Organization and regulations to limit the carcinogenic effects. Toxic and carcinogenic substances standards index. Multi-stage of carcinogenesis. Initiators and promoters. Labeling of toxic substances in food. Cancer prevention through food.
Опис: The subject of the discipline, its content and place in the educational process. General principles of carcinogenic danger. Organization and regulatory documents regarding the limitation of carcinogenic effects. Classification of carcinogens. Carcinogenesis is a polyetiological disease. Tumor suppressors are cell cycle regulators. Blast transformation. Viral oncogenesis. Metabolic transformations of toxic substances. Food biosafety. Cancer prevention.
Assessment methods and criteria: Written report on laboratory work, oral questioning - 20 points, individual research work – 20 points; Final control (test) – 60 points: written form - 50 points, oral test - 10 points.
Критерії оцінювання результатів навчання: Current control (PC) – 40: Written reports for laboratory works, oral survey - 20 Control work (abstract, presentation) - 20 Final test work - 50 including (Oral component – 10)
Порядок та критерії виставляння балів та оцінок: 100–88 points – (“excellent”) is awarded for a high level of knowledge (some inaccuracies are allowed) of the educational material of the component contained in the main and additional recommended literary sources, the ability to analyze the phenomena being studied in their interrelationship and development, clearly, succinctly, logically, consistently answer the questions, the ability to apply theoretical provisions when solving practical problems; 87–71 points – (“good”) is awarded for a generally correct understanding of the educational material of the component, including calculations, reasoned answers to the questions posed, which, however, contain certain (insignificant) shortcomings, for the ability to apply theoretical provisions when solving practical tasks; 70 – 50 points – (“satisfactory”) awarded for weak knowledge of the component’s educational material, inaccurate or poorly reasoned answers, with a violation of the sequence of presentation, for weak application of theoretical provisions when solving practical problems; 49-26 points - ("not certified" with the possibility of retaking the semester control) is awarded for ignorance of a significant part of the educational material of the component, significant errors in answering questions, inability to apply theoretical provisions when solving practical problems; 25-00 points - ("unsatisfactory" with mandatory re-study) is awarded for ignorance of a significant part of the educational material of the component, significant errors in answering questions, inability to navigate when solving practical problems, ignorance of the main fundamental provisions.
Recommended books: 1. Toxicology of food products: a textbook/S. A. Voronov, Yu.B. Stetsyshyn, Yu.V. Panchenko, A.M. Kohut. - Lviv: V-vo Lvivskoi politekhniky, 2014. — 556 p. 2. Ecological biotechnology. Book I: textbook/Shved O.V., Mykoliv O. B., Komarovska-Porokhniavets O.Z. - Lviv: V-vo Lvivskoi politekhniky, 2014. — 357 p. 3. Ecological biotechnology. Book I: textbook/Shved O.V., Mykoliv O. B., Komarovska-Porokhniavets O.Z. - Lviv: V-vo Lvivskoi politekhniky, 2014. — 416 p. 4. Yaremko Z. Life safety: Education manual - K.: Tsentr navchalnoi literatury, 2005. -317 p. 5. Xu H , Raafat el-Gewely M . p53-responsive genes and the potential for cancer diagnostics and therapeutics development. Biotechnol Annu Rev. 2001;7:131–64.
Уніфікований додаток: Lviv Polytechnic National University ensures the realization of the right of persons with disabilities to obtain higher education. Inclusive educational services are provided by the Service of accessibility to learning opportunities "Without restrictions", the purpose of which is to provide permanent individual support for the educational process of students with disabilities and chronic diseases. An important tool for the implementation of the inclusive educational policy at the University is the Program for improving the qualifications of scientific and pedagogical workers and educational and support staff in the field of social inclusion and inclusive education. Contact at: St. Karpinsky, 2/4, 1st floor, room 112 E-mail: nolimits@lpnu.ua Websites: https://lpnu.ua/nolimits https://lpnu.ua/integration
Академічна доброчесність: The policy regarding the academic integrity of the participants of the educational process is formed on the basis of compliance with the principles of academic integrity, taking into account the norms "Regulations on academic integrity at the Lviv Polytechnic National University" (approved by the academic council of the university on June 20, 2017, protocol No. 35).