Chemistry of Carcinogens

Major: Pharmacy, Industrial Pharmacy
Code of subject: 6.226.02.E.097
Credits: 3.00
Department: Technology of Biologically Active Substances, Pharmacy and Biotechnology
Lecturer: Associate Professor, Ph.D. Olena Iaremkevych Professor, D. Sc. Viktoria Havryliak
Semester: 7 семестр
Mode of study: денна
Learning outcomes: - Ability to use knowledge about the impact of harmful factors on the health of living organisms, the methodology for determining the toxicity of xenobiotics in the environment and the processes of provoking oncogenesis; - Ability to apply basic knowledge about the sources and types of carcinogens to prevent their harmful effects on the human body through the consumption of water, food and human exposure to environmentally hazardous environments; - Ability to organize work in accordance with the requirements of life safety and labor protection; - Ability to use knowledge and practical skills to choose quality food products (raw materials) to ensure their own and socially harmonious development and health; - Ability to use knowledge of modern methods of prevention, diagnosis and treatment of cancer. - Ability to demonstrate an understanding of the basics of environmental protection and life safety; - Ability to apply modern experimental methods to assess water and soil quality in the laboratory and in production conditions.
Required prior and related subjects: Prerequisites: General and organic chemistry; Hygiene, human diagnostics and ecomonitoring. Co-requisites: Fundamentals of labor protection and life safety; Technological practice; Biodamage and biotransformation organic compounds.
Summary of the subject: General principles of carcinogenic hazard. Sources of pollution of the biosphere by organic and inorganic carcinogens (nature disasters, man-made disasters, metabolic transformation, anthropogenic emissions). Pollution of food by heavy metals, radionuclides, nitrates and nitrites, microbial metabolites. Organization and regulations to limit the carcinogenic effects. Toxic and carcinogenic substances standards index. Multi-stage of carcinogenesis. Initiators and promoters. Labeling of toxic substances in food. Cancer prevention through food.
Assessment methods and criteria: Written report on laboratory work, oral questioning - 20 points, individual research work – 20 points; Final control (test) – 60 points: written form - 50 points, oral test - 10 points.
Recommended books: 1. Toxicology of food products: a textbook/S. A. Voronov, Yu.B. Stetsyshyn, Yu.V. Panchenko, A.M. Kohut. - Lviv: V-vo Lvivskoi politekhniky, 2014. — 556 p. 2. Ecological biotechnology. Book I: textbook/Shved O.V., Mykoliv O. B., Komarovska-Porokhniavets O.Z. - Lviv: V-vo Lvivskoi politekhniky, 2014. — 357 p. 3. Ecological biotechnology. Book I: textbook/Shved O.V., Mykoliv O. B., Komarovska-Porokhniavets O.Z. - Lviv: V-vo Lvivskoi politekhniky, 2014. — 416 p. 4. Yaremko Z. Life safety: Education manual - K.: Tsentr navchalnoi literatury, 2005. -317 p. 5. Chemical-toxicological determination of xenobiotics. Flying poisons. S.A. Havrylova, N.B. Melnykova, 2006. 6. Xu H , Raafat el-Gewely M . p53-responsive genes and the potential for cancer diagnostics and therapeutics development. Biotechnol Annu Rev. 2001;7:131–64.