Evalution of Biological activity of Chemical Substunses

Major: Biotechnology and Bioengineering
Code of subject: 6.162.00.M.067
Credits: 6.00
Department: Technology of Biologically Active Substances, Pharmacy and Biotechnology
Lecturer: Ass.prof., PhD Komarovska-Porokhnyavets Olena
Semester: 6 семестр
Mode of study: денна
Learning outcomes: • knowledge of the methods of virtual screening of biological active compounds; • knowledge of the methods of experimental research of biological activity of chemical compounds; • ability to choose and apply a biological model in the research of biological effects of compounds; • ability to use statistical methods in medical biological researches; • ability to carry out a comparative analysis of the virtual computer screening results and data of experimental researches of biological activity of new chemical compounds
Required prior and related subjects: • Organic chemistry • General microbiology and virology • Cell biology • Molecular biology Co-requisites: • Bioengineering (Cell and Genetic) • Bioinformatics • Methodology and Organisation of Scientific Investigations, Intellectual Property and Innovation Theory
Summary of the subject: The concept of biological activity of chemical compounds. Issues, tasks and perspectives in the study of biological effects of chemical substances. Test systems and biological models of research of biological activity of compounds. Characteristics of study methods of biological activity of new chemical substances. Prediction of biological activity in silico. Computer programs PASS (Prediction of Activity Spectra for Substances), AVCpred (Antiviral Compound Prediction), CLC-Pred (Cell Line Cytotoxicity Predictor). Experimental methods of studying biological activity of compounds in vitro and in vivo. Computer design of biological active compounds.
Assessment methods and criteria: • current control: written reports for laboratory works, oral examination, written tests (40%) • summary control: examination (exam) written-oral form (60%)
Recommended books: 1. Методики клинических лабораторных исследований. Т. 3. Клиническая микробиология : справочное пособие / под ред. В. В. Меньшикова. – М. : Лабора, 2009. – 880 с. 2. Державна Фармакопея України : в 3 т. / Державне підприємство «Український науковий фармакопейний центр якості лікарських засобів». — 2-е вид. — Харків: Державне підприємство «Україн ський науковий фармакопейний центр якості лікарських засобів», 2015. — Т. 1. — 1128 с. 3. PASS [Електронний ресурс]. – Режим доступу: http://www. ibmh.msk.su/PASS. 4. Наказ МОЗ України №167 від 05.04.2007 р. про затвердження методичних вказівок «Визначення чутливості мікроорганізмів до антибактеріальних препаратів» // Новости медицины и фармации. – 2008. - №236. – С.2-4. [Електронний ресурс. – Режим доступу: h://www.mif-ua.com/archive/article print /4835].